Altered hippocampal volume and functional connectivity in males withInternet gaming disorder comparing to those with alcohol use disorder

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474460.do
DOI
10.1038/s41598-017-06057-7
Title
Altered hippocampal volume and functional connectivity in males withInternet gaming disorder comparing to those with alcohol use disorder
Description
None of the authors have any conflicts of interests to this study. Thiswork was supported by a grant from the Korea Healthcare Technology R&DProject, Ministry for Health and Welfare, Republic of Korea (HI12C-0113)and by the National Research Foundation of Korea (NRF) grant funded bythe Korea government (MSIP) (Nos 2011-0030815, 2014M3C7A1046042, and2014M3C7A1062894).
abstract
Internet gaming disorder (IGD) has been conceptualized as a behavioral addiction and shares clinical, neuropsychological, and personality characteristics with alcohol use disorder (AUD), but IGD dose not entail brain exposure to toxic agents, which renders it different from AUD. To achieve a clear understanding of the neurobiological features of IGD, we aimed to identify morphological and functional changes in IGD and compare them with those in AUD. Individuals with IGD showed larger volume in the hippocampus/amygdala and precuneus than healthy controls (HCs). The volume in the hippocampus positively correlated with the symptom severity of IGD. Moreover, functional connectivity analysis with the hippocampus/amygdala cluster revealed that the left ventromedial prefrontal cortex showed stronger functional connectivity in individuals with IGD compared to those with AUD. In contrast, individuals with AUD exhibited the smaller cerebellar volume and thinner medial frontal cortex than HCs. The volume in the cerebellum correlated with impaired working memory function as well as duration of illness in AUD group. Findings suggested that altered volume and functional connectivity in the hippocampus/amygdala in IGD might be associated with abnormally enhanced memory process of gaming-related cues, while abnormal cortical changes and cognitive impairments in AUD might be associated with neurotoxic effects of alcohol.
provenance
Made available in Cube on 2018-09-28T10:46:39Z (GMT). No. of bitstreams: 0
language
English
author
Yoon, Eun Jin
Choi, Jung-Seok
Kim, Heejung
Sohn, Bo Kyung
Jung, Hee Yeon
Lee, Jun-Young
Kim, Dai-Jin
Park, Sun-Won
Kim, Yu Kyeong
orcid
Lee, Jun-Young/0000-0002-5893-3124
accessioned
2018-09-28T10:46:39Z
available
2018-09-28T10:46:39Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474460.do
Funder
보건복지부
Funding Program
질환극복기술개발
Project ID
1465020376
Jurisdiction
Rep.of Korea
Project Name
Identification of neurobiological marker for developing behavioral addiction and its application to the treatment
rights
openAccess
type
article


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