Alterations in protein phosphorylation in the amygdala of the 5XFamilialAlzheimer's disease animal model

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474450.do
DOI
10.1016/j.jphs.2017.03.005
Title
Alterations in protein phosphorylation in the amygdala of the 5XFamilialAlzheimer's disease animal model
Description
This study was financially supported by grants from the Korea HealthcareTechnology R&D Project (HI3C1451) of Ministry for Health, Welfare andFamily Affairs of the Republic of Korea. In addition, this work wassupported by the Brain Korea 21 PLUS program. The funders had no role instudy design, data collection and analysis, interpretation of data orpreparation of the manuscript.
abstract
Alzheimer's disease is the most common disease underlying dementia in humans. Two major neuropathological hallmarks of AD are neuritic plaques primarily composed of amyloid beta peptide and neurofibrillary tangles primarily composed of hyperphosphorylated tau. In addition to impaired memory function, AD patients often display neuropsychiatric symptoms and abnormal emotional states such as confusion, delusion, manic/depressive episodes and altered fear status. Brains from AD patients show atrophy of the amygdala which is involved in fear expression and emotional processing as well as hippocampal atrophy. However, which molecular changes are responsible for the altered emotional states observed in AD remains to be elucidated. Here, we observed that the fear response as assessed by evaluating fear memory via a cued fear conditioning test was impaired in 5XFamilial AD (5XFAD) mice, an animal model of AD. Compared to wild-type mice, 5XFAD mice showed changes in the phosphorylation of twelve proteins in the amygdala. Thus, our study provides twelve potential protein targets in the amygdala that may be responsible for the impairment in fear memory in AD. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
provenance
Made available in Cube on 2018-09-28T10:46:23Z (GMT). No. of bitstreams: 0
language
English
author
Yang, Eun-Jeong
Mahmood, Usman
Kim, Hyunju
Choi, Moonseok
Choi, Yunjung
Lee, Jean-Pyo
Chang, Moon-Jeong
Kim, Hye-Sun
accessioned
2018-09-28T10:46:23Z
available
2018-09-28T10:46:23Z
issued
2017
citation
JOURNAL OF PHARMACOLOGICAL SCIENCES(133): 4
issn
1347-8613
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474450.do
Funder
보건복지부
Funding Program
질환극복기술개발
Project ID
1465018851
Jurisdiction
Rep.of Korea
Project Name
A study on the regulation of neural circuit formation by cell type-specific expression of microRNAs and the involvement in the impairment of social interaction behavior in autism
rights
openAccess
subject
Alzheimer's disease
Amygdala
Cued fear conditioning
5XFamilialAlzheimer's disease mice
Protein phosphorylation
type
article


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