alpha-Mangostin ameliorates hepatic steatosis and insulin resistance byinhibition C-C chemokine receptor 2

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474442.do
DOI
10.1371/journal.pone.0179204
Title
alpha-Mangostin ameliorates hepatic steatosis and insulin resistance byinhibition C-C chemokine receptor 2
Description
This research was supported by the Basic Science Research Programthrough the National Research Foundation of Korea (NRF) funded by theMinistry of Science, ICT and Future Planning (NRF-2016R1A6A3A11932829).
abstract
Obesity induces various metabolic diseases such as dyslipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes. Fat expansion in adipose tissue induces adipose tissue dysfunction and inflammation, insulin resistance, and other metabolic syndromes. alpha-Mangostin (alpha-MG) has been previously studied for its anti-cancer, anti-inflammatory, and antioxidant activities. In this study, we investigated the effects of alpha-MG on adipose tissue inflammation and hepatic steatosis. We categorized study animals into four groups: regular diet control mice, RD mice treated with alpha-MG, high fat diet-induced obese mice, and HFD mice treated with alpha-MG. alpha-MG treatment significantly reduced not only the body, liver, and fat weights, but also plasma glucose, insulin, and triglyceride levels in HFD mice. Additionally, adiponectin levels of alpha-MG-treated mice were significantly higher than those of control HFD mice. Immunohistochemistry of liver and adipose tissue showed that CD11c expression was reduced in alpha-MG fed obese mice. alpha-MG treatment of HFD mice down-regulated the adipose-associated inflammatory cytokines and CCR2 in both liver and adipose tissue. Moreover, glucose tolerance and insulin sensitivity were significantly improved in alpha-MG fed obese mice. alpha-Mangostin ameliorates adipose inflammation and hepatic steatosis in HFDinduced obese mice.
provenance
Made available in Cube on 2018-09-28T10:46:10Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Hong Min
Kim, You Mi
Huh, Ji Hye
Lee, Eun Soo
Kwon, Mi Hye
Lee, Bo Ra
Ko, Hyun-Jeong
Chung, Choon Hee
accessioned
2018-09-28T10:46:10Z
available
2018-09-28T10:46:10Z
issued
2017
citation
PLOS ONE(12): 6
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474442.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345274253
Jurisdiction
Rep.of Korea
Project Name
The researcher training program for developing novel neuroprotective and anti-inflammatory agents
rights
openAccess
type
article


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