All-printed highly sensitive 2D MoS2 based multi-reagent immunosensorfor smartphone based point-of-care diagnosis

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474431.do
DOI
10.1038/s41598-017-06265-1
Title
All-printed highly sensitive 2D MoS2 based multi-reagent immunosensorfor smartphone based point-of-care diagnosis
Description
This work was supported by the BK21 plus program of the NationalResearch Foundation (NRF) funded by the Ministry of Education of Korea(22A20152913424).
abstract
Immunosensors are used to detect the presence of certain bio-reagents mostly targeted at the diagnosis of a condition or a disease. Here, a general purpose electrical immunosensor has been fabricated for the quantitative detection of multiple bio-reagents through the formation of an antibody-antigen pair. The sensors were fabricated using all printing approaches. 2D transition metal dichalcogenide (TMDC) MoS2 thin film was deposited using Electrohydrodynamic atomization (EHDA) on top of an interdigitated transducer (IDT) electrode fabricated by reverse offset printing. The sensors were then treated with three different types of antibodies that were immobilized by physisorption into the highly porous multi-layered structure of MoS2 active layer. BSA was used as blocking agent to prevent non-specific absorption (NSA). The sensors were then employed for the targeted detection of the specific antigens including prostate specific antigen (PSA), mouse immunoglobulin-G (IgG), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B). IgG was then selected to test the sensors for point of care (POC) diagnosis through a specially designed electronic readout system for sensors and interfacing it with a smartphone using Bluetooth connection. The sensors showed promising performance in terms of stability, specificity, repeatability, sensitivity, limit of detection (LoD), and range of detection (RoD).
provenance
Made available in Cube on 2018-09-28T10:45:53Z (GMT). No. of bitstreams: 0
language
English
author
Sajid, Memoon
Osman, Ahmed
Siddiqui, Ghayas Uddin
Kim, Hyun Bum
Kim, Soo Wan
Ko, Jeong Bum
Lim, Yoon Kyu
Choi, Kyung Hyun
accessioned
2018-09-28T10:45:53Z
available
2018-09-28T10:45:53Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474431.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345274313
Jurisdiction
Rep.of Korea
Project Name
Human Resource Training Center for Smart Devices based on Multi-materials Additive Manufacturing
rights
openAccess
type
article


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