Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2pathway-mediated defense mechanisms in the marine copepod Paracyclopinanana

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474348.do
DOI
10.1038/srep41323
Title
Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2pathway-mediated defense mechanisms in the marine copepod Paracyclopinanana
Description
This work was supported by grants from the Development of Techniques forAssessment and Management of Hazardous Chemicals in the MarineEnvironment of the Ministry of Oceans and Fisheries, Korea to Jae-SeongLee, and was also supported by a grant from the National ResearchFoundation (35423) of Korea to Heum Gi Park.
abstract
Microplastic pollution causes a major concern in the marine environment due to their worldwide distribution, persistence, and adverse effects of these pollutants in the marine ecosystem. Despite its global presence, there is still a lack of information on the effect of microplastics on marine organisms at the molecular level. Herein we demonstrated ingestion and egestion of nano-(0.05 mu m) and micro-sized (0.5 and 6 mu m) polystyrene microbeads in the marine copepod Paracyclopina nana, and examined molecular responses to exposure to microbeads with in vivo endpoints such as growth rate and fecundity. Also, we proposed an adverse outcome pathway for microplastic exposure that covers molecular and individual levels. This study provides the first insight into the mode of action in terms of microplastic-induced oxidative stress and related signaling pathways in P. nana.
provenance
Made available in Cube on 2018-09-28T10:43:40Z (GMT). No. of bitstreams: 0
language
English
author
Jeong, Chang-Bum
Kang, Hye-Min
Lee, Min-Chul
Kim, Duck-Hyun
Han, Jeonghoon
Hwang, Dae-Sik
Souissi, Sami
Lee, Su-Jae
Shin, Kyung-Hoon
Park, Heum Gi
Lee, Jae-Seong
orcid
Lee, Jae-Seong/0000-0003-0944-5172; Shin, Kyung-Hoon/0000-0002-3169-4274
accessioned
2018-09-28T10:43:40Z
available
2018-09-28T10:43:40Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474348.do
Funder
해양수산부
Funding Program
해양수산환경기술개발
Project ID
1525006999
Jurisdiction
Rep.of Korea
Project Name
해양환경 유해물질의 평가 및 관리기술 개발
rights
openAccess
type
article


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