Administration of Zinc plus Cyclo-(His-Pro) Increases HippocampalNeurogenesis in Rats during the Early Phase of Streptozotocin-InducedDiabetes

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474331.do
DOI
10.3390/ijms18010073
Title
Administration of Zinc plus Cyclo-(His-Pro) Increases HippocampalNeurogenesis in Rats during the Early Phase of Streptozotocin-InducedDiabetes
Description
We thank Moon Ki Song (VA Greater Los Angles Healthcare System, LosAngeles, CA, USA) for generously donating the ZC with or without zinc.This work was supported by the Brain Research Program through theNational Research Foundation of Korea (NRF) funded by the Ministry ofScience, ICT & Future Planning (NRF-2016M3C7A1913844) to Sang Won Suh.
abstract
The effects of zinc supplementation on hippocampal neurogenesis in diabetes mellitus have not been studied. Herein, we investigated the effects of zinc plus cyclo-(His-Pro) (ZC) on neurogenesis occurring in the subgranular zone of dentate gyrus after streptozotocin (STZ)-induced diabetes. ZC (27 mg/kg) was administered by gavage once daily for one or six weeks from the third day after the STZ injection, and histological evaluation was performed at 10 (early phase) or 45 (late phase) days after STZ injection. We found that the proliferation of progenitor cells in STZ-induced diabetic rats showed an increase in the early phase. Additionally, ZC treatment remarkably increased the number of neural progenitor cells (NPCs) and immature neurons in the early phase of STZ-induced diabetic rats. Furthermore, ZC treatment showed increased survival rate of newly generated cells but no difference in the level of neurogenesis in the late phase of STZ-induced diabetic rats. The present study demonstrates that zinc supplementation by ZC increases both NPCs proliferation and neuroblast production at the early phase of diabetes. Thus, this study suggests that zinc supplemented with a histidine/proline complex may have beneficial effects on neurogenesis in patients experiencing the early phase of Type 1 diabetes.
provenance
Made available in Cube on 2018-09-28T10:43:12Z (GMT). No. of bitstreams: 0
language
English
author
Choi, Bo Young
Kim, In Yeol
Kim, Jin Hee
Lee, Bo Eun
Lee, Song Hee
Kho, A. Ra
Sohn, Min
Suh, Sang Won
orcid
SOHN, MIN/0000-0003-4021-2051
accessioned
2018-09-28T10:43:12Z
available
2018-09-28T10:43:12Z
issued
2017
citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(18): 1
issn
1422-0067
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474331.do
Funder
과학기술정보통신부
Funding Program
뇌과학원천기술개발
Project ID
1711051586
Jurisdiction
Rep.of Korea
Project Name
Development of technology for early diagnosis and overcoming cerebral microcirculation dysfunction
rights
openAccess
subject
zinc
zinc plus cyclo-(His-Pro)
neurogenesis
hippocampus
diabetes
streptozotocin
type
article


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