Adipose Tissue Formation Utilizing Fat Flap Distraction Technique

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474328.do
DOI
10.1038/s41598-017-05547-y
Title
Adipose Tissue Formation Utilizing Fat Flap Distraction Technique
abstract
Co-regulation between adipocytes and supporting vasculature is considered an important process in adipose tissue generation. The objective of this study was to evaluate the mechanical and biological effects of a distraction technique on adipose tissue formation and maintenance. Based on the hypothesis that fat flaps gradually receding from each other can develop an adipose tissue construct, perforated polycarbonate syringe-shaped chambers were implanted in a rabbit model. Latency (1 week) and distraction (3 weeks) periods were followed by a consolidation period in the experimental groups (4, 8, and 12 weeks). In the distraction group, the volume of fat pad gradually increased up to 16 weeks. A transition zone was observed at 8 weeks, indicating the initiation of tissue generation. Histomorphologic analysis showed adipose and collagen connective tissue at 8 weeks. At 16 weeks, the relative composition was altered significantly. Adipose components occupied most of the tissue, and connective tissue was reduced. Blood vessels with endothelial lining were noted adjacent to adipocyte clusters, as well as in inter-adipocyte areas. The vessels had increased in number and were evenly distributed by 16 weeks. Our distraction technique produced more balanced adipose tissue generation than a non-distraction method, with co-development of adipose and vascular tissues.
provenance
Made available in Cube on 2018-09-28T10:43:07Z (GMT). No. of bitstreams: 0
language
English
author
Lee, Myung Chul
Lee, Won Jai
Lee, Byung Il
Chung, Kee Yang
Kim, Jae Woo
Kang, Eun Hye
Kim, Yong Oock
accessioned
2018-09-28T10:43:07Z
available
2018-09-28T10:43:07Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474328.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345274063
Jurisdiction
Rep.of Korea
Project Name
Project of Yonsei Medical Science
rights
openAccess
type
article


Files in This Item

There are no attached files.