Adiponectin Signaling Regulates Lipid Production in Human Sebocytes

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474325.do
DOI
10.1371/journal.pone.0169824
Title
Adiponectin Signaling Regulates Lipid Production in Human Sebocytes
Description
This study was supported by a grant of the Korea Healthcare technologyR&D Project, Ministry of Health & Welfare, Republic of Korea. (Grant No.: HI14C1379).
abstract
Adiponectin plays important roles in metabolic function, inflammation and multiple biological activities in various tissues. However, evidence for adiponectin signaling in sebaceous glands is lacking, and its role remains to be clarified. This study investigated the role of adiponectin in lipid production in sebaceous glands in an experimental study of human sebocytes. We demonstrated that human sebaceous glands in vivo and sebocytes in vitro express adiponectin receptor and that adiponectin increased cell proliferation. Moreover, based on a lipogenesis study using Oil Red O, Nile red staining and thin layer chromatography, adiponectin strongly upregulated lipid production in sebocytes. In three-dimensional culture of sebocytes, lipid synthesis was markedly enhanced in sebocytes treated with adiponectin. This study suggested that adiponectin plays a significant role in human sebaceous gland biology. Adiponectin signaling is a promising target in the clinical management of barrier disorders in which sebum production is decreased, such as in atopic dermatitis and aged skin.
provenance
Made available in Cube on 2018-09-28T10:43:02Z (GMT). No. of bitstreams: 0
language
English
author
Jung, Yu Ra
Lee, Jin-Hyup
Sohn, Kyung-Cheol
Lee, Young
Seo, Young-Joon
Kim, Chang-Deok
Lee, Jeung-Hoon
Hong, Seung-Phil
Seo, Seong-Jun
Kim, Seong-Jin
Im, Myung
accessioned
2018-09-28T10:43:02Z
available
2018-09-28T10:43:02Z
issued
2017
citation
PLOS ONE(12): 1
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474325.do
Funder
보건복지부
Funding Program
글로벌화장품신소재·신기술연구개발지원
Project ID
1465024757
Jurisdiction
Rep.of Korea
Project Name
Identification of the adiponectin-specific signaling pathway for improvement of aged skin barrier function via sebum production
rights
openAccess
type
article


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