Adiponectin Regulates the Polarization and Function of Microglia viaPPAR-gamma Signaling Under Amyloid beta Toxicity

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474324.do
DOI
10.3389/fncel.2017.00064
Title
Adiponectin Regulates the Polarization and Function of Microglia viaPPAR-gamma Signaling Under Amyloid beta Toxicity
Description
This study was supported by the Brain Research Program through theNational Research Foundation of Korea funded by the Ministry of Science,ICT and Future Planning NRF-2016M3C7A1905469 (BCK) and a grant from2016R1D1A1B03930394 (JS).
abstract
Alzheimer's disease (AD), characterized by the abnormal accumulation of amyloid beta (A beta), is gradually increasing globally. Given that AD is considered a neuroinflammatory disease, recent studies have focused on the cellular mechanisms in brain inflammatory conditions that underlie AD neuropathology. Microglia are macrophage cells in the central nervous system (CNS) that are activated in response to A beta condition. The function of microglia contributes to the neuroinflammation in AD brain, suggesting that microglia regulate the production of inflammatory mediators and contribute to the regeneration of damaged tissues. Adiponectin, an adipokine derived from adipose tissue, has been known to regulate inflammation and control macrophages during oxidative stress conditions. In present study, we investigated whether adiponectin influences the polarization and function of microglia under A beta toxicity by examining alterations of BV2 microglia function and polarization by Acrp30 (a globular form of adiponectin) treatment using reverse transcription PCR, western blotting and immunofluorescence staining. Acrp30 promoted the induction of the M2 phenotype, and regulated the inflammatory responses through peroxisome proliferator-activated receptor (PPAR)-gamma signaling under A beta toxicity. In addition, Acrp30 boosted the capacity of A beta scavenging in microglia. Taken together, we suggest that adiponectin may control the function of microglia by promoting anti-inflammatory responses through PPAR- gamma signaling. Hence, we conclude that adiponectin may act as a critical controller of microglia function in the AD brain.
provenance
Made available in Cube on 2018-09-28T10:43:01Z (GMT). No. of bitstreams: 0
language
English
author
Song, Juhyun
Choi, Seong-Min
Kim, Byeong C.
accessioned
2018-09-28T10:43:01Z
available
2018-09-28T10:43:01Z
issued
2017
citation
FRONTIERS IN CELLULAR NEUROSCIENCE(11)
issn
1662-5102
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474324.do
Funder
과학기술정보통신부
Funding Program
뇌과학원천기술개발
Project ID
1711048578
Jurisdiction
Rep.of Korea
Project Name
A cohort study of the Alzheimer's disease patient based on multimodal biomarkers
rights
openAccess
subject
adiponectin
Acrp30
microglia
inflammation
amyloid beta (A beta)
cytokines
peroxisome proliferator-activated receptor (PPAR)-gamma
type
article


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