Acupuncture points can be identified as cutaneous neurogenicinflammatory spots

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474268.do
DOI
10.1038/s41598-017-14359-z
Title
Acupuncture points can be identified as cutaneous neurogenicinflammatory spots
Description
Drs Kim HY and Yang CH were supported by grants from the NationalResearch Foundation of Korea (2014R1A2A1A11053104) and the KoreaInstitute of Oriental Medicine (K17070). Dr. Ryu YH was supported by theKorea Institute of Oriental Medicine (K17070).
abstract
Acupuncture, a traditional medical procedure practised for over 2000 years in Asia, stimulates specific but poorly defined sites called acupoints. To date, no unique anatomical acupoint structures have been found. However, noxious sensory signals from visceral organs produce hypersensitive spots on the skin (neurogenic spots), caused by cutaneous neurogenic inflammation, in the dermatome that overlaps with visceral afferent innervations. Here, we show that an acupoint is one form of neurogenic inflammation on the skin. Various studies have demonstrated that acupoints show mechanical hypersensitivity and have high electrical conductance. Stimulation of acupoints produces needling sensations caused by the activation of small diameter afferent nerve fibres and therapeutic effects on the associated visceral organs, which is likely due to the release of endogenous opioids. The present study provides experimental evidence that neurogenic spots exhibit all the characteristics of the acupoints listed above. In addition, the stimulation of neurogenic spots by electrical, mechanical, or chemical means alleviated pathological conditions in rat colitis and hypertension models via the endogenous opioid system. Our results suggest that acupoints associated with internal organs may be identical to neurogenic inflammatory spots on the skin, which are produced by activation of somatic afferents in abnormal conditions of visceral organs.
provenance
Made available in Cube on 2018-09-28T10:41:34Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Do-Hee
Ryu, Yeonhee
Hahm, Dae Hyun
Sohn, Boo Yong
Shim, Insop
Kwon, O. Sang
Chang, Suchan
Gwak, Young Seob
Kim, Min Sun
Kim, Jae Hyo
Lee, Bong Hyo
Jang, Eun Young
Zhao, Rongjie
Chung, Jin Mo
Yang, Chae Ha
Kim, Hee Young
accessioned
2018-09-28T10:41:34Z
available
2018-09-28T10:41:34Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474268.do
Funder
과학기술정보통신부
Funding Program
한국한의학연구원연구운영비지원
Project ID
1711063922
Jurisdiction
Rep.of Korea
Project Name
A study on the peripheral-spinal-cerebral signaling pathway of acupuncture stimulus
rights
openAccess
type
article


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