ACTN3 Gene and Susceptibility to Sarcopenia and Osteoporotic Status inOlder Korean Adults

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474256.do
DOI
10.1155/2017/4239648
Title
ACTN3 Gene and Susceptibility to Sarcopenia and Osteoporotic Status inOlder Korean Adults
Description
The National Research Foundation Grant funded by the Korean Government(NRF-2015S1A5B5A02012775) supported this work.
abstract
Background. Little information is available about molecular markers for sarcopenia and osteoporosis in Asian populations. Objective. This study investigated the association of the ACTN3 polymorphism with sarcopenia and osteoporotic status in older Korean adults. Methods. Older Korean 62 men and 270 women (mean age 73.7 +/- 6.6 years) participated in this study. Body mass index, percent body fatness, appendicular skeletalmuscle mass, and bone mineral density of the lumbar spine, femur, and total body were analyzed with dual-energy X-ray absorptiometry. ACTN3 R/X genotyping was determined using TaqMan probes. Results. Determination of odds ratios (ORs) and 95% confidence intervals (CIs) using binary logistic regression analyses showed that XX homozygotes were at a significantly higher risk of sarcopenia (OR = 2.056, 95% CI = 1.024-4.127, p = 0.043) and osteoporosis (OR = 2.794, 95% CI = 1.208-5.461, p = 0.016) than RR homozygotes (reference group, OR = 1). The OR of XX homozygotes for having sarcopenia remained significant (OR = 2.237, 95% CI = 1.044-4.836, p = 0.038) after adjustments for age, gender, body fatness, and serum vitamin D. The OR of XX homozygotes for having osteoporosis was no longer significant (OR = 2.682, 95% CI = 0.960-7.942, p = 0.075) after adjustments for the covariates. Conclusion. Our findings suggest that the ACTN3 R577X genotype may influence decline in muscle and bone health phenotypes in older Korean adults.
provenance
Made available in Cube on 2018-09-28T10:41:16Z (GMT). No. of bitstreams: 0
language
English
author
Cho, Jinkyung
Lee, Inhwan
Kang, Hyunsik
orcid
KANG, HYUNSIK/0000-0002-8611-1873
accessioned
2018-09-28T10:41:16Z
available
2018-09-28T10:41:16Z
issued
2017
citation
BIOMED RESEARCH INTERNATIONAL
issn
2314-6133
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474256.do
Funder
교육부
Funding Program
인문사회기초연구
Project ID
1345267105
Jurisdiction
Rep.of Korea
Project Name
The effect of treadmill running on cognitive impairment and neuropathology in familial Alzheimer’s disease
rights
openAccess
type
article


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