Acidic Polysaccharide Extracts from Gastrodia Rhizomes Suppress theAtherosclerosis Risk Index through Inhibition of the Serum CholesterolComposition in Sprague Dawley Rats Fed a High-Fat Diet

Collection with item attached
2012
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474211.do
DOI
10.3390/ijms13021620
Title
Acidic Polysaccharide Extracts from Gastrodia Rhizomes Suppress theAtherosclerosis Risk Index through Inhibition of the Serum CholesterolComposition in Sprague Dawley Rats Fed a High-Fat Diet
Description
This research was supported by Technology Development Program for Food,Ministry for Food, Agriculture, Forestry and Fisheries, Republic ofKorea to H.-D. Hong.
abstract
Obesity is associated with a broad spectrum of cardio-metabolic disturbances, including atherosclerosis and cardiovascular disease (CDV). A high-fat diet has been shown to cause an elevation of the plasma cholesterol levels in humans, and the control of serum cholesterol has been demonstrated to be important in the prevention of CVD and atherosclerosis. The aims of this study were to demonstrate that crude and acidic polysaccharide extracts from Gastrodia rhizomes suppress atherosclerosis through the regulation of serum lipids in Sprague Dawley (SD) rats fed a high-fat diet. We examined the concentrations of serum lipids, including total cholesterol, triglycerides, high-density lipoproteins (HDL) cholesterol, and low-density lipoproteins (LDL) cholesterol, in SD rats fed a high-fat diet and evaluated the atherogenic index. Here, we show that both crude and acidic polysaccharide extracts from Gastrodia rhizomes inhibited the total cholesterol and LDL levels. Moreover, there was a significantly suppressed atherosclerosis risk due to the acidic polysaccharide extract from Gastrodia rhizome. Taken together, our results suggested that acidic polysaccharide extracts from Gastrodia rhizomes might be beneficial for lowering the incidence of CVD and atherosclerosis by reducing the de novo synthesis of total cholesterol and the LDL levels.
provenance
Made available in Cube on 2018-09-28T10:40:06Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Kui-Jin
Lee, Ok-Hwan
Han, Chan-Kyu
Kim, Young-Chan
Hong, Hee-Do
orcid
Wang, Yi/0000-0003-1567-3358; Lee, Ok-Hwan/0000-0001-6855-3136
accessioned
2018-09-28T10:40:06Z
available
2018-09-28T10:40:06Z
issued
2012
citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(13): 2
issn
1422-0067
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474211.do
Funder
지식경제부
Funding Program
한국식품연구원연구운영비지원
Project ID
1415125828
Jurisdiction
Rep.of Korea
Project Name
Development of Functional Foods for Body Protection from Korean traditional
rights
openAccess
subject
Gastrodia rhizome
acidic polysaccharide
cardio vascular disease
atherogenic index
type
article


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