Accelerated biodegradation of silk sutures through matrixmetalloproteinase activation by incorporating 4-hexylresorcinol

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474176.do
DOI
10.1038/srep42441
Title
Accelerated biodegradation of silk sutures through matrixmetalloproteinase activation by incorporating 4-hexylresorcinol
Description
This work was carried out with the support of "Cooperative ResearchProgram for Agriculture Science and Technology Development (Project No.PJ01121404)", Rural Development Administration, Republic of Korea.
abstract
Silk suture material is primarily composed of silk fibroin and regarded as a non-resorbable material. It is slowly degraded by proteolysis when it is implanted into the body. 4-Hexylresorcinol (4HR) is a well-known antiseptic. In this study, the biodegradability of 4HR-incorporated silk sutures were compared to that of untreated silk sutures and polyglactin 910 sutures, a commercially available resorbable suture. 4HR-incorporated silk sutures exhibited anti-microbial properties. Matrix metalloproteinase (MMP) can digest a wide spectrum of proteins. 4HR increased MMP-2, -3, and -9 expression in RAW264.7 cells. MMP-2, -3, and -9 were able to digest not only silk fibroin but also silk sutures. Consequently, 59.5% of the 4HR-incorporated silk suture material remained at 11 weeks after grafting, which was similar to that of polyglactin 910 degradation (56.4% remained). The residual amount of bare silk suture material at 11 weeks after grafting was 91.5%. The expression levels of MMP-2, -3 and -9 were high in the 4HR-incorporated silk suture-implanted site 12 weeks after implantation. In conclusion, 4HR-treated silk sutures exhibited anti-microbial properties and a similar level of bio-degradation to polyglactin 910 sutures and induced higher expression of MMP-2, -3, and -9 in macrophages.
provenance
Made available in Cube on 2018-09-28T10:39:12Z (GMT). No. of bitstreams: 0
language
English
author
Jo, You-Young
Kweon, HaeYong
Kim, Dae-Won
Kim, Min-Keun
Kim, Seong-Gon
Kim, Jwa-Young
Chae, Weon-Sik
Hong, Sam-Pyo
Park, Young-Hwan
Lee, SiYoung
Choi, Je-Yong
accessioned
2018-09-28T10:39:12Z
available
2018-09-28T10:39:12Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474176.do
Funder
과학기술정보통신부
Funding Program
한국기초과학지원연구원연구운영비지원
Project ID
1711063451
Jurisdiction
Rep.of Korea
Project Name
Analytical Research
rights
openAccess
type
article


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