Aberrant neural networks for the recognition memory of socially relevantinformation in patients with schizophrenia

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474164.do
DOI
10.1002/brb3.602
Title
Aberrant neural networks for the recognition memory of socially relevantinformation in patients with schizophrenia
Description
"Biomedical Integrated Technology Research" Project through a grantprovided by GIST; National Research Foundation of Korea (NRF) grantfunded by the Korea government (MEST), Grant/Award Number:NRF-2013R1A2A2A03068342
abstract
IntroductionPatients with schizophrenia exhibit several cognitive deficits, including memory impairment. Problems with recognition memory can hinder socially adaptive behavior. Previous investigations have suggested that altered activation of the frontotemporal area plays an important role in recognition memory impairment. However, the cerebral networks related to these deficits are not known. The aim of this study was to elucidate the brain networks required for recognizing socially relevant information in patients with schizophrenia performing an old-new recognition task.
MethodsSixteen patients with schizophrenia and 16 controls participated in this study. First, the subjects performed the theme-identification task during functional magnetic resonance imaging. In this task, pictures depicting social situations were presented with three words, and the subjects were asked to select the best theme word for each picture. The subjects then performed an old-new recognition task in which they were asked to discriminate whether the presented words were old or new. Task performance and neural responses in the old-new recognition task were compared between the subject groups. An independent component analysis of the functional connectivity was performed.
ResultsThe patients with schizophrenia exhibited decreased discriminability and increased activation of the right superior temporal gyrus compared with the controls during correct responses. Furthermore, aberrant network activities were found in the frontopolar and language comprehension networks in the patients.
ConclusionsThe functional connectivity analysis showed aberrant connectivity in the frontopolar and language comprehension networks in the patients with schizophrenia, and these aberrations possibly contribute to their low recognition performance and social dysfunction. These results suggest that the frontopolar and language comprehension networks are potential therapeutic targets in patients with schizophrenia.
provenance
Made available in Cube on 2018-09-28T10:38:53Z (GMT). No. of bitstreams: 0
language
English
author
Oh, Jooyoung
Chun, Ji-Won
Kim, Eunseong
Park, Hae-Jeong
Lee, Boreom
Kim, Jae-Jin
accessioned
2018-09-28T10:38:53Z
available
2018-09-28T10:38:53Z
issued
2017
citation
BRAIN AND BEHAVIOR(7): 1
issn
2162-3279
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474164.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345274063
Jurisdiction
Rep.of Korea
Project Name
Project of Yonsei Medical Science
rights
openAccess
subject
frontopolar network
functional magnetic resonance imaging
independentcomponent analysis
language comprehension network
recognition memory
schizophrenia
type
article


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