A Tumor-pH-Responsive Supramolecular Photosensitizer for ActivatablePhotodynamic Therapy with Minimal In Vivo Skin Phototoxicity

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474114.do
DOI
10.7150/thno.18861
Title
A Tumor-pH-Responsive Supramolecular Photosensitizer for ActivatablePhotodynamic Therapy with Minimal In Vivo Skin Phototoxicity
Description
This research was supported by the National Natural Science Foundationof China (Grant Nos. 21473033, 21301031), Specialized Research Fund forthe Doctoral Program of Higher Education (Grant No. 201135141001), and agrant from the National Creative Research Initiative programs of theNational Research Foundation of Korea (NRF) funded by the Koreangovernment (MSIP) (No. 2012R1A3A2048814).
abstract
A major challenge in photodynamic therapy (PDT) is the development of new tumor-targeting photosensitizers. The tumor-specific activation is considered to be an effective strategy for designing these photosensitizers. Herein, we describe a novel tumor-pH-responsive supramolecular photosensitizer, LDH-ZnPcS8, which is not photoactive under neutral conditions but is precisely and efficiently activated in a slightly acidic environment (pH 6.5). LDH-ZnPcS8 is prepared by using a simple coprecipitation method based on the electrostatic interaction between negatively charged octasulfonate-modified zinc(II) phthalocyanine (ZnPcS8) and cationic hydroxide layers of layered double hydroxide (LDH). The in vitro photodynamic activities of LDH-ZnPcS8 in cancer cells are dramatically enhanced relative to those of ZnPcS8 alone. The results of in vivo fluorescence imaging demonstrate that the nanohybrid is activated in tumor tissues, where it displays an excellent PDT effect resulting in 95.3% tumor growth inhibition. Furthermore, the minimal skin phototoxicity of LDH-ZnPcS8 highlights its high potential as a novel photosensitizer for activatable PDT.
provenance
Made available in Cube on 2018-09-28T10:37:35Z (GMT). No. of bitstreams: 0
language
English
author
Li, Xingshu
Zheng, Bi-Yuan
Ke, Mei-Rong
Zhang, Yongfan
Huang, Jian-Dong
Yoon, Juyoung
orcid
Huang, Jian-Dong/0000-0003-0798-0147
accessioned
2018-09-28T10:37:35Z
available
2018-09-28T10:37:35Z
issued
2017
citation
THERANOSTICS(7): 10
issn
1838-7640
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474114.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345273987
Jurisdiction
Rep.of Korea
Project Name
Department of Chemistry and Nanoscience
rights
openAccess
subject
photodynamic therapy
activatable photosensitizer
skin phototoxicity
layered double hydroxide
phthalocyanine
type
article


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