A temperature sensitive Mycobacterium paragordonae induces enhancedprotective immune responses against mycobacterial infections in themouse model

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474101.do
DOI
10.1038/s41598-017-15458-7
Title
A temperature sensitive Mycobacterium paragordonae induces enhancedprotective immune responses against mycobacterial infections in themouse model
Description
This research was supported by the National Research Foundation of Korea(NRF) and funded by the Ministry of Education (Grant No.NRF-2016R1A2B4011847). Bo-Ram Kim received a scholarship from theBK21-plus education program provided by the National Research Foundationof Korea.
abstract
Recently, we introduced a temperature sensitive Mycobacterium spp., Mycobacterium paragordonae (Mpg). Here, we checked its potential as a candidate for live vaccination against Mycobacterium tuberculosis and Mycobacterium abscessus. Intravenous infections of mice with Mpg led to lower colony forming units (CFUs) compared to infection with BCG, suggesting its usefulness as a live vaccine. The analyses of immune responses indicated that the highly protective immunity elicited by Mpg was dependent on effective dendritic maturation, shift of cytokine patterns and antibody production toward a Th1 phenotype, and enhanced cytotoxic T cell response. Compared to BCG, Mpg showed a more effective protective immune response in the vaccinated mice against challenges with 2 different mycobacterial strains, M. tuberculosis H37Ra or M. abscessus Asan 50594. Our data suggest that a temperature sensitive Mpg may be a potentially powerful candidate vaccine strain to induce enhanced protective immune responses against M. tuberculosis and M. abscessus.
provenance
Made available in Cube on 2018-09-28T10:37:14Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Byoung-Jun
Kim, Bo-Ram
Kook, Yoon-Hoh
Kim, Bum-Joon
accessioned
2018-09-28T10:37:14Z
available
2018-09-28T10:37:14Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474101.do
Funder
과학기술정보통신부
Funding Program
개인기초연구(미래부)
Project ID
1711054697
Jurisdiction
Rep.of Korea
Project Name
Study of bacteriological and immunological traits on a temperature sensitive mycobacterial strain as a live attenuated tuberculosis vaccine
rights
openAccess
type
article


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