A simple rat model of mild traumatic brain injury: a device to reproduceanatomical and neurological changes of mild traumatic brain injury

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474011.do
DOI
10.7717/peerj.2818
Title
A simple rat model of mild traumatic brain injury: a device to reproduceanatomical and neurological changes of mild traumatic brain injury
Description
This research was supported by Basic Science Research Program throughthe National Research Foundation of Korea (NRF) funded by the Ministryof Education (NRF-2013R1A1A2059711) and Research Grant of AlumniChapters of Medical College of Ewha Womans University in 2015. Thefunders had no role in study design, data collection and analysis,decision to publish, or preparation of the manuscript.
abstract
Mild traumatic brain injury typically involves temporary impairment of neurological function. Previous studies used water pressure or rotational injury for designing the device to make a rat a mild traumatic brain injury model. The objective of this study was to make a simple model of causing mild traumatic brain injury in rats. The device consisted of a free-fall impactor that was targeted onto the rat skull. The weight (175 g) was freely dropped 30 cm to rat's skull bregma. We installed a safety device made of acrylic panel. To confirm a mild traumatic brain injury in 36 Sprague-Dawley rats, we performed magnetic resonance imaging (MRI) of the brain within 24 h after injury. We evaluated behavior and chemical changes in rats before and after mild traumatic brain injury. The brain MRI did not show high or low signal intensity in 34 rats. The mobility on grid floor was decreased after mild traumatic brain injury. The absolute number of foot-fault and foot-fault ratio were decreased after mild traumatic brain injury. However, the difference of the ratio was a less than absolute number of foot-fault. These results show that the device is capable of reproducing mild traumatic brain injury in rats. Our device can reduce the potential to cause brain hemorrhage and reflect the mechanism of real mild traumatic brain injury compared with existing methods and behaviors. This model can be useful in exploring physiology and management of mild traumatic brain injury.
provenance
Made available in Cube on 2018-09-28T10:34:51Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Ho Jeong
Han, Soo Jeong
accessioned
2018-09-28T10:34:51Z
available
2018-09-28T10:34:51Z
issued
2017
citation
PEERJ(5)
issn
2167-8359
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474011.do
Funder
교육부
Funding Program
이공학개인기초연구지원
Project ID
1345239807
Jurisdiction
Rep.of Korea
Project Name
Effect of transcranial direct current stimulation on corticospinal motor excitability and biochemial metabolism in concussion model of rats
rights
openAccess
subject
Concussion
Rat
Device
Methodology
type
article


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