A novel association between relaxin receptor polymorphism andhematopoietic stem cell yield after mobilization

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/473810.do
DOI
10.1371/journal.pone.0179986
Title
A novel association between relaxin receptor polymorphism andhematopoietic stem cell yield after mobilization
Description
This work was supported by a grant from the Korean Health Technology R&DProject, Ministry of Health and Welfare, Republic of Korea (A120030,http://www.htdream.kr/, KAL). The funder had no role in study design,data collection and analysis, decision to publish, or preparation of themanuscript.
abstract
Mobilization of hematopoietic stem cells (HSCs) from the bone marrow to the peripheral blood is a complex mechanism that involves adhesive and chemotactic interactions of HSCs as well as their bone marrow microenvironment. In addition to a number of non-genetic factors, genetic susceptibilities also contribute to the mobilization outcome. Identification of genetic factors associated with HSC yield is important to better understand the mechanism behind HSC mobilization. In the present study, we enrolled 148 Korean participants (56 healthy donors and 92 patients) undergoing HSC mobilization for allogeneic or autologous HSC transplantation. Among a total of 53 polymorphisms in 33 candidate genes, one polymorphism (rs11264422) in relaxin/insulin-like family peptide receptor 4 (RXFP4) gene was significantly associated with a higher HSC yield after mobilization in Koreans. However, in a set of 101 Europeans, no association was found between circulating CD34+ cell counts and rs11264422 genotype. Therefore, we suggest that the ethnic differences in subjects' genetic background may be related to HSC mobilization. In conclusion, the relaxin-relaxin receptor axis may play an important role in HSC mobilization. We believe that the results of the current study could provide new insights for therapies that use relaxin and HSC populations, as well as a better understanding of HSC regulation and mobilization at the molecular level.
provenance
Made available in Cube on 2018-09-28T10:29:27Z (GMT). No. of bitstreams: 0
language
English
author
Shin, Saeam
Kim, Juwon
Kim-Wanner, Soo-Zin
Boenig, Halvard
Cho, Sung Ran
Kim, Sinyoung
Choi, Jong Rak
Lee, Kyung-A
accessioned
2018-09-28T10:29:27Z
available
2018-09-28T10:29:27Z
issued
2017
citation
PLOS ONE(12): 6
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/473810.do
Funder
보건복지부
Funding Program
질환극복기술개발
Project ID
1465023680
Jurisdiction
Rep.of Korea
Project Name
Clinical characterization and development of therapeutic materials of storage diseases through metabolomic and transcriptomic study
rights
openAccess
type
article


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