A Multimodal Biomicroscopic System based on High-frequency AcousticRadiation Force Impulse and Multispectral Imaging Techniques for TumorCharacterization Ex vivo

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/473751.do
DOI
10.1038/s41598-017-17367-1
Title
A Multimodal Biomicroscopic System based on High-frequency AcousticRadiation Force Impulse and Multispectral Imaging Techniques for TumorCharacterization Ex vivo
Description
This work has been supported by National Research Foundation of Koreaunder Grant NRF-2017R1A2B4010726 and NRF-2017M3A9G8084463 for J.Y. Hwangat DGIST and partially supported by DGIST under HRHR Grant(17-01-HRMA-02).
abstract
We report a multimodal biomicroscopic system which offers high-frequency ultrasound B-mode, acoustic radiation force impulse (ARFI), and multispectral imaging for qualitative tumor characterization ex vivo. Examinations of resected tissues from diseased regions such as tumors are crucial procedures during surgical operations to treat cancer. Particularly, if tiny tumors remain at surgical sites after tumor resection, such tumors can result in unwanted outcomes, such as cancer recurrence or metastasis to other organs. To avoid this, accurate characterizations of tumors resected during surgery are necessary. To this end, we devised a multimodal biomicroscopic system including high-frequency ultrasound B-mode, ARFI, and multispectral imaging modalities to examine resected tumors with high levels of accuracy. This system was evaluated with tissue-mimicking phantoms with different mechanical properties. In addition, colorectal tumors excised from cancer patients were examined. The proposed system offers highly resolved anatomical, mechanical, chemical information pertaining to tumors, thus allowing the detection of tumor regions from the surface to deep inside tissues. These results therefore suggest that the multimodal biomicroscopic system has the potential to undertake qualitative characterizations of excised tumors ex vivo.
provenance
Made available in Cube on 2018-09-28T10:27:54Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Jihun
Seo, Anna
Kim, Jun-Young
Choi, Sung Hyouk
Yoon, Hyung-Jin
Kim, Eunjoo
Hwang, Jae Youn
accessioned
2018-09-28T10:27:54Z
available
2018-09-28T10:27:54Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/473751.do
Funder
과학기술정보통신부
Funding Program
대구경북과학기술원연구운영비지원(0.5)
Project ID
1711063419
Jurisdiction
Rep.of Korea
Project Name
암 조직 분자 진단을 위한 다중 모달 융합 내시경 개발
rights
openAccess
type
article


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