A Local Counter-Regulatory Motif Modulates the Global Phase of HormonalOscillations

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/473692.do
DOI
10.1038/s41598-017-01806-0
Title
A Local Counter-Regulatory Motif Modulates the Global Phase of HormonalOscillations
Description
We thank Arthur Sherman, Vipul Periwal, Erik Gylfe, Anders Tengholm, BoHellman, Jong Bhak, and Jaekyoung Kim for helpful comments. Thisresearch was supported by Basic Science Research Program through theNational Research Foundation of Korea (NRF) funded by the Ministry ofEducation (2016R1D1A1B03932264) and the Max Planck Society, the KoreaMinistry of Education, Science and Technology, Gyeongsangbuk-Do andPohang City (J.J.).
abstract
Counter-regulatory elements maintain dynamic equilibrium ubiquitously in living systems. The most prominent example, which is critical to mammalian survival, is that of pancreatic alpha and beta cells producing glucagon and insulin for glucose homeostasis. These cells are not found in a single gland but are dispersed in multiple micro-organs known as the islets of Langerhans. Within an islet, these two reciprocal cell types interact with each other and with an additional cell type: the delta cell. By testing all possible motifs governing the interactions of these three cell types, we found that a unique set of positive/negative intra-islet interactions between different islet cell types functions not only to reduce the superficially wasteful zero-sum action of glucagon and insulin but also to enhance/suppress the synchronization of hormone secretions between islets under high/normal glucose conditions. This antisymmetric interaction motif confers effective controllability for network (de) synchronization.
provenance
Made available in Cube on 2018-09-28T10:26:21Z (GMT). No. of bitstreams: 0
language
English
author
Park, Dong-Ho
Song, Taegeun
Hoang, Danh-Tai
Xu, Jin
Jo, Junghyo
accessioned
2018-09-28T10:26:21Z
available
2018-09-28T10:26:21Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/473692.do
Funder
과학기술정보통신부
Funding Program
아태이론물리센터지원
Project ID
1711062052
Jurisdiction
Rep.of Korea
Project Name
APCTP
rights
openAccess
type
article


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