A High-Affinity Repebody for Molecular Imaging of EGFR-ExpressingMalignant Tumors

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/473651.do
DOI
10.7150/thno.18096
Title
A High-Affinity Repebody for Molecular Imaging of EGFR-ExpressingMalignant Tumors
Description
This research was supported by the Pioneer Research Center Program(2015M3C1A3056410), Bio & Medical Technology Development Program(NRF-2014M3A9B5073747) of the National Research Foundation (NRF) fundedby the Ministry of Science, ICT & Future Planning. J.-J.M. was supportedby the grant of CNUH-GIST (CRI15072-3), H.-S.K. was supported by theGlobal Research Laboratory Program (NRF-2015K1A1A2033346), Mid-careerResearcher Program (NRF-2014R1A2A1A01004198) of the National ResearchFoundation (NRF), and Brain Korea 21 funded by the Ministry ofEducation, J.Y.K. was supported by the Radiation Technology R&D program(NRF-2012M2A2A7013480) and D.Y.K. was supported by the National ResearchFoundation of Korea (NRF-2015M2B2A9031798) funded by the Ministry ofScience, ICT & Future Planning (D.-Y.K.). W.S.L was supported by thegrant (HCRI14025-1) from the Chonnam National University Hwasun HospitalInstitute for Biomedical Science.
abstract
The accurate detection of disease-related biomarkers is crucial for the early diagnosis and management of disease in personalized medicine. Here, we present a molecular imaging of human epidermal growth factor receptor (EGFR)-expressing malignant tumors using an EGFR-specific repebody composed of leucine-rich repeat (LRR) modules. The repebody was labeled with either a fluorescent dye or radioisotope, and used for imaging of EGFR-expressing malignant tumors using an optical method and positron emission tomography. Our approach enabled visualization of the status of EGFR expression, allowing quantitative evaluation in whole tumors, which correlated well with the EGFR expression levels in mouse or patients-derived colon cancers. The present approach can be effectively used for the accurate detection of EGFR-expressing cancers, assisting in the development of a tool for detecting other disease biomarkers.
provenance
Made available in Cube on 2018-09-28T10:25:16Z (GMT). No. of bitstreams: 0
language
English
author
Yun, Misun
Kim, Dong-Yeon
Lee, Joong-jae
Kim, Hyeon-Sik
Kim, Hyung-Seok
Pyo, Ayoung
Ryu, Yiseul
Kim, Tae-Yoon
Zheng, Jin Hai
Yoo, Su Woong
Hyun, Hoon
Oh, Gyungseok
Jeong, Jaeho
Moon, Myeongju
Min, Jung-Hyun
Kwon, Seong Young
Kim, Jung Young
Chung, Euiheon
Hong, Yeongjin
Lee, Wansik
Kim, Hak-Sung
Min, Jung-Joon
accessioned
2018-09-28T10:25:16Z
available
2018-09-28T10:25:16Z
issued
2017
citation
THERANOSTICS(7): 10
issn
1838-7640
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/473651.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345274073
Jurisdiction
Rep.of Korea
Project Name
Center for Creative Biomedical Scientists at Chonnam National University
rights
openAccess
subject
Repebody
Epidermal growth factor receptor
Colon cancer
Molecularimaging
PET
Optical imaging
type
article


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