A conserved neuronal DAF-16/FoxO plays an important role in conveyingpheromone signals to elicit repulsion behavior in Caenorhabditis elegans

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/473529.do
DOI
10.1038/s41598-017-07313-6
Title
A conserved neuronal DAF-16/FoxO plays an important role in conveyingpheromone signals to elicit repulsion behavior in Caenorhabditis elegans
Description
We thank the Caenorhabditis Genetics Center (funded by the NIH Office ofResearch Infrastructure Programs (P40 OD10440)) for providing mutantworms. We thank Dr. David Miller III for the gift of glna-3P::gfptransgenic animals. We thank Dr. E.-S. Kwon for his gifts of DAF-16/FoxOisoforms and related double mutants for this work. This work wassupported by the National Research Foundation of Korea to YKP(2011-0028112) and DP (2013R1A1A2009033).
abstract
Animals use pheromones as a conspecific chemical language to respond appropriately to environmental changes. The soil nematode Caenorhabditis elegans secretes ascaroside pheromones throughout the lifecycle, which influences entry into dauer phase in early larvae, in addition to sexual attraction and aggregation. In adult hermaphrodites, pheromone sensory signals perceived by worms usually elicit repulsion as an initial behavioral signature. However, the molecular mechanisms underlying neuronal pheromone sensory process from perception to repulsion in adult hermaphrodites remain poorly understood. Here, we show that pheromone signals perceived by GPA-3 is conveyed through glutamatergic neurotransmission in which neuronal DAF-16/FoxO plays an important modulatory role by controlling glutaminase gene expression. We further provide evidence that this modulatory role for DAF-16/FoxO seems to be conserved evolutionarily by electro-physiological study in mouse primary hippocampal neurons that are responsible for glutamatergic neurotransmission. These findings provide the basis for understanding the nematode pheromone signaling, which seems crucial for adaptation of adult hermaphrodites to changes in environmental condition for survival.
provenance
Made available in Cube on 2018-09-28T10:22:05Z (GMT). No. of bitstreams: 0
language
English
author
Park, Donha
Hahm, Jeong-Hoon
Park, Saeram
Ha, Go
Chang, Gyeong-Eon
Jeong, Haelim
Kim, Heekyeong
Kim, Sunhee
Cheong, Eunji
Paik, Young-Ki
accessioned
2018-09-28T10:22:05Z
available
2018-09-28T10:22:05Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/473529.do
Funder
과학기술정보통신부
Funding Program
개인기초연구(미래부)
Project ID
1711048887
Jurisdiction
Rep.of Korea
Project Name
Elucidation of Molecular Mechanism Underlying the Cross-Regulatory Roles of Pheromone and Hormones Involving C. elegans Development in Response to Starvation Stress
rights
openAccess
type
article


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