A comparative study of biological and metabolic biomarkers betweenhealthy individuals and patients with acne vulgaris: A cross-sectionalstudy protocol

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/473505.do
DOI
10.1097/MD.0000000000008554
Title
A comparative study of biological and metabolic biomarkers betweenhealthy individuals and patients with acne vulgaris: A cross-sectionalstudy protocol
Description
This study was supported by the Traditional Korean Medicine R&D programfunded by the Ministry of Health and Welfare through the Korea HealthIndustry Development Institute (HI16C0801).
abstract
Acne is a multifactorial dermatosis, which is influenced not only by hormones but also by the biochemical relationship between them and the pilosebaceous unit. Inflammatory cytokines, chemokines, active oxygen, and zinc are known to be associated with the development of acne. Further, steroid metabolism is known as one of the important factors related to sebum secretion and comedone formation in acne. However, there is a lack of studies comparing these human biomarkers between healthy individuals and patients with acne. In particular, no study has investigated the relationship between human biomarkers and patterns of acne yet.The purpose of this study is to investigate diagnostic human biomarkers in acne by comparing the biological and metabolic biomarkers between healthy individuals and patients with acne and identify the relationship between human biomarkers and patterns of acne.This study is a protocol for a cross-sectional study. Forty healthy participants and 60 patients with acne will be recruited at 1 center. We will collect their blood samples and analyze the molecular biological and metabolic biomarkers (cytokines, chemokines, reactive oxygen species, corticotropin-releasing hormone, zinc, amino acid, 1-carbon metabolite, lipid metabolite, etc.). Further, we will administer questionnaires regarding their diet, sleep, stress, and other factors relating to acne and measure their skin elasticity.The study protocol was approved by the Institutional Review Board of Oriental Medical Hospital at Kyung Hee Medical Center (KOMCIRB-161118-HR-062). Written informed consent will be obtained from all the participants. The trial was registered in the Clinical Research Information Service, Republic of Korea: KCT0002212.This trial will provide evidence regarding diagnostic human biomarkers in acne and the relationship between the human biomarkers and patterns of acne.
provenance
Made available in Cube on 2018-09-28T10:21:24Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Kyuseok
Ha, Injin
Kim, Eunok
Kim, Kyunglee
accessioned
2018-09-28T10:21:24Z
available
2018-09-28T10:21:24Z
issued
2017
citation
MEDICINE(96): 45
issn
0025-7974
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/473505.do
Funder
보건복지부
Funding Program
한의약선도기술개발
Project ID
1465022793
Jurisdiction
Rep.of Korea
Project Name
A study of in vitro models and metabolomics/molecular biological biomarkers for acne based on the Korean Medicine theory
rights
openAccess
subject
acne vulgaris
biological biomarkers
diagnosis
metabolic biomarkers
patterns of acne
type
article


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