A Combination of Soybean and Haematococcus Extract AlleviatesUltraviolet B-Induced Photoaging

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/473501.do
DOI
10.3390/ijms18030682
Title
A Combination of Soybean and Haematococcus Extract AlleviatesUltraviolet B-Induced Photoaging
Description
This work was supported by Korea Institute of Planning and Evaluationfor Technology in Food, Agriculture, Forestry and Fisheries (IPET)through Agri-Bio industry Technology Development Program (514004),funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA),Republic of Korea, and Korea Institute for Advancement of Technology(KIAT) through R&D program (Establishment of Infra Structure forAnti-aging Industry Support, No. N0000697), funded by Ministry of Trade,Industry and Energy (MOTIE), Republic of Korea.
abstract
Soybean-derived isoflavones have been investigated for their preventative effects against UV-induced symptoms of skin damage including wrinkle formation and inflammation. Haematococcus pluvialis is a freshwater species of Chlorophyta that contains high concentrations of the natural carotenoid pigment astaxanthin. Astaxanthin is known to be involved in retinoic acid receptor (RAR) signaling and previously been associated with the inhibition of activator protein (AP)-1 dependent transcription. Based on previous studies, we hypothesized that a combination of soy extract (SE) and Haematococcus extract (HE) may prevent UVB-induced photoaging through specific signaling pathways, as measured by UVB-induced wrinkling on hairless mice skin and expression changes in human dermal fibroblasts (HDFs). The 1: 2 ratio of SE and HE mixture (SHM) showed the optimal benefit in vivo. SHM was found to inhibit wrinkle formation via the downregulation of matrix metalloproteinase (MMP)-1 mRNA and protein expression. SHM also inhibited mitogen-activated protein kinase (MAPK) phosphorylation and the transactivation of AP-1 which plays an important role in regulating MMP expression. These results highlight the potential for SHM to be developed as a therapeutic agent to prevent UVB-induced skin wrinkling.
provenance
Made available in Cube on 2018-09-28T10:21:18Z (GMT). No. of bitstreams: 0
language
English
author
Shin, Jieun
Kim, Jong-Eun
Pak, Kum-Ju
Kang, Jung Il
Kim, Tae-Seok
Lee, Sang-Yoon
Yeo, Ik-Hyun
Park, Jung Han Yoon
Kim, Jong Hun
Kang, Nam Joo
Lee, Ki Won
orcid
Park, Jung Han Yoon/0000-0002-5518-4279
accessioned
2018-09-28T10:21:18Z
available
2018-09-28T10:21:18Z
issued
2017
citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(18): 3
issn
1422-0067
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/473501.do
Funder
농림축산식품부
Funding Program
고부가가치식품기술개발
Project ID
1545014170
Jurisdiction
Rep.of Korea
Project Name
IoT 스마트팜 기반 피부건강 개선 맞춤형 새싹삼 생산 및 이를 활용한 글로벌 기능성 식품 소재 개발
rights
openAccess
subject
soybean
Haematococcus
ultraviolet B
photoaging
type
article


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