A Benzochalcone Derivative,(E)-1-(2-hydroxy-6-methoxyphenyl)-3-(naphthalen-2-yl)prop-2-en-1-one(DK-512), Inhibits Tumor Invasion through Inhibition of the TNFalpha-Induced NF-kappa B/MMP-9 Axis in MDA-MB-231 Breast Cancer Cells

Collection with item attached
2016
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/473471.do
DOI
10.1155/2016/4921717
Title
A Benzochalcone Derivative,(E)-1-(2-hydroxy-6-methoxyphenyl)-3-(naphthalen-2-yl)prop-2-en-1-one(DK-512), Inhibits Tumor Invasion through Inhibition of the TNFalpha-Induced NF-kappa B/MMP-9 Axis in MDA-MB-231 Breast Cancer Cells
Description
This research was supported by Basic Science Research Program throughthe National Research Foundation of Korea (NRF) funded by the Ministryof Science, ICT, and Future Planning (NRF-2016R1A2B4008570). This paperwas supported by the KU Research Professor Program of Konkuk University.
abstract
Tumor invasion is a critical step in tumor metastasis. In this study, we synthesized a novel benzochalcone derivative, (E)-1-(2-hydroxy-6-methoxyphenyl)-3-(naphthalen-2-yl)prop-2-en-1-one (DK-512), and characterized its effects on tumor invasion and its mechanism of action. We found that DK-512 strongly inhibited invasion of metastatic MDA-MB-231 breast cancer cells as revealed by a three-dimensional spheroid culture system. Tumor invasion and metastasis require disruption of the extracellular matrix. Matrix metalloproteinase-9 (MMP-9) is an endopeptidase that degrades extracellular matrix components. DK-512 significantly reduced tumor necrosis factor-alpha-(TNF alpha-) induced MMP-9 mRNA expression through the inhibition of RelA nuclear factor-(NF-) kappa B transcription factor. As our study was assessed in vitro, further works about in vivo efficacy of DK-512 are needed to gain further insights into whether DK-512 could be utilized as a scaffold for the development of antimetastatic agents for breast cancer.
provenance
Made available in Cube on 2018-09-28T10:20:29Z (GMT). No. of bitstreams: 0
language
English
author
Shin, Soon Young
Kim, Chang Gun
Ahn, Seunghyun
Jung, You Jung
Koh, Dongsoo
Lee, Young Han
Lim, Yoongho
orcid
ahn, seunghyun/0000-0002-5069-9513
accessioned
2018-09-28T10:20:29Z
available
2018-09-28T10:20:29Z
issued
2016
citation
JOURNAL OF CHEMISTRY
issn
2090-9063
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/473471.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345258249
Jurisdiction
Rep.of Korea
Project Name
Division of Bioscience and Biotechnology
rights
openAccess
type
article


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