4-Hydroxybenzaldehyde accelerates acute wound healing through activationof focal adhesion signalling in keratinocytes
- Collection with item attached
-
2017
- Item details URL
-
http://open-repository.kisti.re.kr/cube/handle/open_repository/473443.do
- DOI
-
10.1038/s41598-017-14368-y
- Title
- 4-Hydroxybenzaldehyde accelerates acute wound healing through activationof focal adhesion signalling in keratinocytes
- abstract
- 4-Hydroxybenzaldehyde (4-HBA) is a naturally occurring benzaldehyde and the major active constituent of Gastrodia elata. While recent studies have demonstrated metabolic effects of 4-HBA, little is known about the physiological role of 4-HBA in acute wound healing. Here, we investigated the effects and mechanisms of 4-HBA on acute wound healing. Using an in vitro approach, we found that 4-HBA significantly promoted keratinocyte cell migration and invasion by increasing focal adhesion kinase and Src activity. In addition, 4-HBA treatment also promoted wound healing and reepithelialization in an in vivo excision wound animal model. Combination treatment with 4-HBA and platelet-derived growth factor subunit B homodimer showed synergistic effects in promoting wound healing. Taken together, our results demonstrated that treatment with 4-HBA promoted keratinocyte migration and wound healing in mouse skin through the Src/mitogen-activated protein kinase pathway. Therefore, 4-HBA could be a candidate therapeutic agent with the potential to promote acute wound healing.
- provenance
- Made available in Cube on 2018-09-28T10:19:43Z (GMT). No. of bitstreams: 0
- language
- English
- author
- Kang, Chan Woo
- Han, Ye Eon
- Kim, Jean
- Oh, Joo Heon
- Cho, Yoon Hee
- Lee, Eun Jig
- accessioned
- 2018-09-28T10:19:43Z
- available
- 2018-09-28T10:19:43Z
- issued
- 2017
- citation
- SCIENTIFIC REPORTS(7)
- issn
- 2045-2322
- uri
- http://open-repository.kisti.re.kr/cube/handle/open_repository/473443.do
- Funder
- 교육부
- Funding Program
- BK21플러스사업(0.5)
- Project ID
- 1345274063
- Jurisdiction
- Rep.of Korea
- Project Name
- Project of Yonsei Medical Science
- rights
- openAccess
- type
- article
- Files in This Item
There are no attached files.