Open-Repository

Item details URL: http://open-repository.kisti.re.kr/cube/handle/open_repository/473443.do

Title: 4-Hydroxybenzaldehyde accelerates acute wound healing through activationof focal adhesion signalling in keratinocytes

abstract: 4-Hydroxybenzaldehyde (4-HBA) is a naturally occurring benzaldehyde and the major active constituent of Gastrodia elata. While recent studies have demonstrated metabolic effects of 4-HBA, little is known about the physiological role of 4-HBA in acute wound healing. Here, we investigated the effects and mechanisms of 4-HBA on acute wound healing. Using an in vitro approach, we found that 4-HBA significantly promoted keratinocyte cell migration and invasion by increasing focal adhesion kinase and Src activity. In addition, 4-HBA treatment also promoted wound healing and reepithelialization in an in vivo excision wound animal model. Combination treatment with 4-HBA and platelet-derived growth factor subunit B homodimer showed synergistic effects in promoting wound healing. Taken together, our results demonstrated that treatment with 4-HBA promoted keratinocyte migration and wound healing in mouse skin through the Src/mitogen-activated protein kinase pathway. Therefore, 4-HBA could be a candidate therapeutic agent with the potential to promote acute wound healing.

provenance: Made available in Cube on 2018-09-28T10:19:43Z (GMT). No. of bitstreams: 0

author: Kang, Chan Woo; Han, Ye Eon; Kim, Jean; Oh, Joo Heon; Cho, Yoon Hee; Lee, Eun Jig

uri: http://open-repository.kisti.re.kr/cube/handle/open_repository/473443.do

4-Hydroxybenzaldehyde accelerates acute wound healing through activationof focal adhesion signalling in keratinocytes