4-Hydroxybenzaldehyde accelerates acute wound healing through activationof focal adhesion signalling in keratinocytes

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/473443.do
DOI
10.1038/s41598-017-14368-y
Title
4-Hydroxybenzaldehyde accelerates acute wound healing through activationof focal adhesion signalling in keratinocytes
abstract
4-Hydroxybenzaldehyde (4-HBA) is a naturally occurring benzaldehyde and the major active constituent of Gastrodia elata. While recent studies have demonstrated metabolic effects of 4-HBA, little is known about the physiological role of 4-HBA in acute wound healing. Here, we investigated the effects and mechanisms of 4-HBA on acute wound healing. Using an in vitro approach, we found that 4-HBA significantly promoted keratinocyte cell migration and invasion by increasing focal adhesion kinase and Src activity. In addition, 4-HBA treatment also promoted wound healing and reepithelialization in an in vivo excision wound animal model. Combination treatment with 4-HBA and platelet-derived growth factor subunit B homodimer showed synergistic effects in promoting wound healing. Taken together, our results demonstrated that treatment with 4-HBA promoted keratinocyte migration and wound healing in mouse skin through the Src/mitogen-activated protein kinase pathway. Therefore, 4-HBA could be a candidate therapeutic agent with the potential to promote acute wound healing.
provenance
Made available in Cube on 2018-09-28T10:19:43Z (GMT). No. of bitstreams: 0
language
English
author
Kang, Chan Woo
Han, Ye Eon
Kim, Jean
Oh, Joo Heon
Cho, Yoon Hee
Lee, Eun Jig
accessioned
2018-09-28T10:19:43Z
available
2018-09-28T10:19:43Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/473443.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345274063
Jurisdiction
Rep.of Korea
Project Name
Project of Yonsei Medical Science
rights
openAccess
type
article


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