4-Hydroxy-2,3-Dimethyl-2-Nonen-4-Olide Has an Inhibitory Effect onPro-Inflammatory Cytokine Production in CpG-Stimulated BoneMarrow-Derived Dendritic Cells

Collection with item attached
2016
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/473442.do
DOI
10.3390/md14050088
Title
4-Hydroxy-2,3-Dimethyl-2-Nonen-4-Olide Has an Inhibitory Effect onPro-Inflammatory Cytokine Production in CpG-Stimulated BoneMarrow-Derived Dendritic Cells
Description
This work was supported by the National Research Foundation of KoreaGrant funded by the Korean Government (MEST)(NRF-C1ABA001-2011-0021037).
abstract
This study was intended to assess the anti-inflammatory properties of 4-hydroxy-2,3-dimethyl-2-nonen-4-olide (Comp) isolated from Ulva pertusa Kjellman on production of pro-inflammatory cytokines. Comp revealed remarkable inhibitory effects on production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs). Comp pre-treatment in the CpG DNA-stimulated BMDCs exhibited strong inhibition of interleukin (IL)-12 p40 and IL-6 production with IC50 values ranging from 7.57 +/- 0.2 to 10.83 +/- 0.3, respectively. It revealed an inhibitory effect on the phosphorylation of ERK1/2, JNK1/2, and p38, and on activator protein (AP)-1 reporter activity. Comp displayed noteworthy inhibitory effects on phosphorylation and degradation of IB, and on NF-B reporter activity. In summary, these data propose that Comp has substantial anti-inflammatory properties and warrants further study concerning its potential use as a therapeutic agent for inflammation-associated maladies.
provenance
Made available in Cube on 2018-09-28T10:19:41Z (GMT). No. of bitstreams: 0
language
English
author
Manzoor, Zahid
Koo, Jung-Eun
Ali, Irshad
Kim, Jung-Eun
Byeon, Sang-Hee
Yoo, Eun-Sook
Kang, Hee-Kyoung
Hyun, Jin-Won
Lee, Nam-Ho
Koh, Young-Sang
accessioned
2018-09-28T10:19:41Z
available
2018-09-28T10:19:41Z
issued
2016
citation
MARINE DRUGS(14): 5
issn
1660-3397
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/473442.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345258435
Jurisdiction
Rep.of Korea
Project Name
Human Resource Development in the Field of Bio-Technological Application of Cellular Activity
rights
openAccess
subject
4-hydroxy-2
3-dimethyl-2-nonen-4-olide
inflammation
activatorprotein-1
pro-inflammatory cytokine
type
article


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