3-Deoxyglucosone: A Potential Glycating Agent Accountable for StructuralAlteration in H3 Histone Protein through Generation of Different AGEs

Collection with item attached
2015
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/473434.do
DOI
10.1371/journal.pone.0116804
Title
3-Deoxyglucosone: A Potential Glycating Agent Accountable for StructuralAlteration in H3 Histone Protein through Generation of Different AGEs
Description
This work was supported by National Research Foundation of Korea grantfunded by the Korea government (MSIP) (No. 2014R1A2A2A01006324).
abstract
Advanced glycation end-products (AGEs) are heterogeneous group of compounds, known to be implicated in diabetic complications. One of the consequences of the Maillard reaction is attributed to the production of reactive intermediate products such as a-oxoaldehydes. 3deoxyglucosone (3-DG), an alpha-oxoaldehyde has been found to be involved in accelerating vascular damage during diabetes. In the present study, calf thymus histone H3 was treated with 3-deoxyglucosone to investigate the generation of AGEs (N-epsilon-carboxymethyllysine, pentosidine), by examining the degree of side chain modifications and formation of different intermediates and employing various physicochemical techniques. The results clearly indicate the formation of AGEs and structural changes upon glycation of H3 by 3-deoxyglucosone, which may hamper the normal functioning of H3 histone, that may compromise the veracity of chromatin structures and function in secondary complications of diabetes.
provenance
Made available in Cube on 2018-09-28T10:19:27Z (GMT). No. of bitstreams: 0
language
English
author
Ashraf, Jalaluddin M.
Ahmad, Saheem
Rabbani, Gulam
Hasan, Qambar
Jan, Arif Tasleem
Lee, Eun Ju
Khan, Rizwan Hasan
Alam, Khursheed
Choi, Inho
orcid
Ashraf, Jalaluddin M/0000-0001-7885-2551; Alam,
Khursheed/0000-0001-9729-9966; Ahmad, Saheem/0000-0003-1215-0279; Khan,
Rizwan Hasan/0000-0002-9965-8982; Rabbani, Gulam/0000-0002-5293-8231
accessioned
2018-09-28T10:19:27Z
available
2018-09-28T10:19:27Z
issued
2015
citation
PLOS ONE(10): 2
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/473434.do
Funder
교육부
Funding Program
BK21플러스사업
Project ID
1345244142
Jurisdiction
Rep.of Korea
Project Name
Serum Biomedical Research and Education Team (SBRET)
rights
openAccess
type
article


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