3 '-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN,and XPO5 Are Associated with Colorectal Cancer Risk in a KoreanPopulation

Collection with item attached
2015
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/473419.do
DOI
10.1371/journal.pone.0131125
Title
3 '-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN,and XPO5 Are Associated with Colorectal Cancer Risk in a KoreanPopulation
Description
National Research Foundation of Korea Grants funded by the KoreanGovernment (NRF-2012R1A1A2007033 & 2009-0093821), Republic of Korea(http://www.nrf.re.kr/). The funders had no role in study design, datacollection and analysis, decision to publish, or preparation of themanuscript.
abstract
MicroRNAs play an important role in cancer initiation and development. The aim of this study was to investigate whether polymorphisms in miRNA machinery genes are associated with the development of colorectal cancer (CRC). RAN rs14035 CT heterozygotes and T allele carriers (CT + TT) genotypes had lower risk of CRC, while the DICER1 rs3742330, DROSHA rs10719, and XPO5 rs11077 polymorphisms were not associated with CRC in the full study sample. Specifically, male RAN rs14035 CT heterozygotes and XPO5 rs11077 AA genotype (CT/AA) carriers experienced reduced CRC susceptibility (both colon and rectal). Subgroup analysis demonstrated that the combined RAN rs14035 CT + TT genotype was associated with rectal cancer, but not colon cancer. In addition, the DICER1 rs3742330 AG genotype was associated with a significantly increased risk of colon cancer. Stratified analysis revealed the RAN rs14035 combined CT+TT genotype was associated with decreased CRC risk in male patients without diabetes mellitus (DM) and in patients with rectal cancer. In addition, we found the RAN rs14035 CC genotype was related to a decreased risk of CRC with respect to tumor size and metabolism of homocysteine and folate. Furthermore, patients diagnosed with hypertension or DM who carried the DROSHA rs10719 CC genotype showed increased CRC risk, while the XPO5 rs11077 AC+CC genotype led to increased CRC risk in patients with hypertension only. Our results indicate variations in RANrs14035, DICER1 rs3742330, XPO5 rs11077, and DROSHA rs10719 of Korean patients are significantly associated with their risk of CRC.
provenance
Made available in Cube on 2018-09-28T10:19:01Z (GMT). No. of bitstreams: 0
language
English
author
Cho, Sung Hwan
Ko, Jung Jae
Kim, Jung Oh
Jeon, Young Joo
Yoo, Jung Ki
Oh, Jisu
Oh, Doyeun
Kim, Jong Woo
Kim, Nam Keun
accessioned
2018-09-28T10:19:01Z
available
2018-09-28T10:19:01Z
issued
2015
citation
PLOS ONE(10): 7
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/473419.do
Funder
교육부
Funding Program
일반연구자지원
Project ID
1345225228
Jurisdiction
Rep.of Korea
Project Name
Association study of miRNA-related gene polymorphisms as predictive markers with idiopathic recurrent spontaneous abortion and recurrent implantation failure and their relation to metabolic syndrome
rights
openAccess
type
article


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