2,4,6-Tribromophenol Interferes with the Thyroid Hormone System byRegulating Thyroid Hormones and the Responsible Genes in Mice

Collection with item attached
2016
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/473412.do
DOI
10.3390/ijerph13070697
Title
2,4,6-Tribromophenol Interferes with the Thyroid Hormone System byRegulating Thyroid Hormones and the Responsible Genes in Mice
Description
This work was supported by the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology (grantnumber: 2015R1A6A1A04020885 and No. 2013-010514). We thank to Ki-Jeong,Na, Chungbuk National University, advices for serum free thyroidhormones measurement and cooperation.
abstract
2,4,6-Tribromophenol (TBP) is a brominated flame retardant (BFR). Based on its affinity for transthyretin, TBP could compete with endogenous thyroid hormone. In this study, the effects of TBP on the thyroid hormone system were assessed in mice. Briefly, animals were exposed to 40 and 250 mg/kg TBP. Thyroid hormones were also administered with or without TBP. When mice were treated with TBP, deiodinase 1 (Dio1) and thyroid hormone receptor beta isoform 2 (Thr beta 2) decreased in the pituitary gland. The levels of deiodinase 2 (Dio2) and growth hormone (Gh) mRNA increased in response to 250 mg/kg of TBP, and the relative mRNA level of thyroid stimulating hormone beta (Tsh beta) increased in the pituitary gland. Dio1 and Thr beta 1 expression in the liver were not altered, while Dio1 decreased in response to co-treatment with thyroid hormones. The thyroid gland activity decreased in response to TBP, as did the levels of free triiodothyronine and free thyroxine in serum. Taken together, these findings indicate that TBP can disrupt thyroid hormone homeostasis and the presence of TBP influenced thyroid actions as regulators of gene expression. These data suggest that TBP interferes with thyroid hormone systems
provenance
Made available in Cube on 2018-09-28T10:18:49Z (GMT). No. of bitstreams: 0
language
English
author
Lee, Dongoh
Ahn, Changhwan
Hong, Eui-Ju
An, Beum-Soo
Hyun, Sang-Hwan
Choi, Kyung-Chul
Jeung, Eui-Bae
orcid
Jeung, Eui-Bae/0000-0001-8936-916X; Ahn, Changhwan/0000-0002-7176-7108;
An, Beum-soo/0000-0002-7052-6564
accessioned
2018-09-28T10:18:49Z
available
2018-09-28T10:18:49Z
issued
2016
citation
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH(13): 7
issn
1660-4601
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/473412.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345258250
Jurisdiction
Rep.of Korea
Project Name
Creative Veterinary Research Group
rights
openAccess
subject
endocrine disruptor
2,4,6-tribromophenol
thyroid hormone
type
article


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