(E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol Enhances Melanogenesis throughIncreasing Upstream Stimulating Factor-1-Mediated Tyrosinase Expression

Collection with item attached
2015
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/473393.do
DOI
10.1371/journal.pone.0141988
Title
(E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol Enhances Melanogenesis throughIncreasing Upstream Stimulating Factor-1-Mediated Tyrosinase Expression
Description
The work was supported by the following: National Research Foundation ofKorea (NRF) grant funded by the Korea government (MSIP), grant number:2012R1A5A1048236 (URL: www.nrf.re.kr); the Korean Health Technology R&DProject, Ministry of Health & Welfare, Republic of Korea, grant number:HI12C0050 (URL: http://www.mw.go.kr); and the Ministry of Science, ICTand Future Planning (NRF2012M3A9C4048761). The funders had roles instudy design, data collection and analysis, decision to publish, orpreparation of the manuscript.
abstract
We investigated the potential melanogenic effect of compounds from Zingiber cassumunar Roxb. Our data revealed that chloroform-soluble extract of Z. cassumunar enhanced melanin synthesis in B16F10 melanoma cells. Among the components of the chloroform extract, (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol (DMPB) increased melanogenesis in both B16F10 cells and human primary melanocytes. In B16F10 cells, DMPB enhanced the activation of ERK and p38, and the level of tyrosinase. Although the level of microphthalmia-associated transcription factor was unchanged in DMPB-treated B16F10 cells, DMPB increased levels and nuclear localization of upstream stimulating factor-1 (USF1). Consistently, DMPB-mediated melanin synthesis was diminished in USF1-knockdown cells. Furthermore, DMPB induced hyperpigmentation in brown guinea pigs in vivo. Together, these data suggest that DMPB may promote melanin synthesis via USF1 dependent fashion and could be used as a clinical therapeutic agent against hypopigmentation-associated diseases.
provenance
Made available in Cube on 2018-09-28T10:18:15Z (GMT). No. of bitstreams: 0
language
English
author
Park, Jisu
Chung, Heesung
Bang, Seung Hyun
Han, Ah-Reum
Seo, Eun-Kyoung
Chang, Sung Eun
Kang, Duk-Hee
Oh, Eok-Soo
accessioned
2018-09-28T10:18:15Z
available
2018-09-28T10:18:15Z
issued
2015
citation
PLOS ONE(10): 11
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/473393.do
Funder
미래창조과학부
Funding Program
선도연구센터지원
Project ID
1711028384
Jurisdiction
Rep.of Korea
Project Name
Research Center for Cellular Homeostasis
rights
openAccess
type
article


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