Bioavailability of soilborne lead in adults, by stable isotope dilution.

Collection with item attached
1998_12
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/442485.do
Title
Bioavailability of soilborne lead in adults, by stable isotope dilution.
Description
Using stable isotope dilution, we determined the bioavailability of soilborne lead (Pb) in human adult volunteers. Soil from a residential yard at a mining-impacted federal Superfund site that had negligible amounts of other priority pollutants was dried and screened through a 25-micron mesh sieve. The < 250-micron fraction, which likely represents that ingested via hand-to-mouth activity, was then sterilized by exposure to radiation. Ten replicate samples yielded a mean (SD) soil Pb concentration of 2924 +/- 36 ppm, and a mean 206Pb/207Pb ratio of 1.1083 +/- 0.0002, indicating remarkable soil homogeneity. Six adults with 206Pb/207Pb ratios of > 1.190 were admitted to the clinical research center and fasted overnight prior to dosing with 250 micrograms Pb/70 kg bw (i.e., 85.5 mg soil/70 kg) in a gelatin capsule. Blood for Pb and 206Pb/207Pb ratios was obtained at 14 time points through 30 hr. Results of the isotopic analyses from these subjects indicate that on average 26.2% +/- 8.1 of the administered dose was absorbed. Six additional subjects were subsequently studied but ingested soil immediately after a standardized breakfast. Bioavailability in this group was only 2.52% +/- 1.7. Collectively, this study provides the first experimental estimates of soil Pb absorption in humans, and should allow for more precise estimates of health risks due to Pb-contaminated soil.
provenance
Made available in Cube on 2016-05-25T22:35:46Z (GMT). No. of bitstreams: 0
language
en
creator
Maddaloni, M
Lolacono, N
Manton, W
Blum, C
Drexler, J
Graziano, J
date
1998-12
accessioned
2016-05-25T22:35:46Z
available
2016-05-25T22:35:46Z
issued
2016-05-26
identifier
/pmc/articles/PMC1533442/
/pubmed/9860919
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/442485.do
rights
subject
Research Article
type
Text


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