Dose-response relationships for carcinogens: a review.

Collection with item attached
1987_08
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/437770.do
Title
Dose-response relationships for carcinogens: a review.
Description
We review the experimental evidence for various shapes of dose-response relationships for carcinogens and summarize those experiments that give the most information on relatively low doses. A brief review of some models is given to illustrate the shapes of dose-response curve expected from them. Our major interest is in the use of dose-response relationships to estimate risks to humans at low doses, and so we pay special attention to experimentally observed and theoretically expected nonlinearities. There are few experimental examples of nonlinear dose-response relations in humans, but this may simply be due to the limitations in the data. The several examples in rodents, even though for high dose data, suggest that nonlinearity is common. In some cases such nonlinearities may be rationalized on the basis of the pharmacokinetics of the test compound or its metabolites.
provenance
Made available in Cube on 2016-05-18T18:06:23Z (GMT). No. of bitstreams: 0
language
en
creator
Zeise, L
Wilson, R
Crouch, E A
date
1987-08
accessioned
2016-05-18T18:06:23Z
available
2016-05-18T18:06:23Z
issued
2016-05-19
identifier
/pmc/articles/PMC1474571/
/pubmed/3311725
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/437770.do
rights
subject
Research Article
type
Text


Files in This Item
envhper00432-0280.gif6KBDownloadView
envhper00432-0267.tif134.5KBDownloadView
envhper00432-0265.gif6KBDownloadView
envhper00432-0247.tif171.7KBDownloadView
envhper00432-0288.gif5.8KBDownloadView
envhper00432-0256.tif200.8KBDownloadView
envhper00432-0263.gif7.4KBDownloadView
envhper00432-0273.tif221.9KBDownloadView
envhper00432-0257.tif194.4KBDownloadView
envhper00432-0281.tif147.6KBDownloadView
envhper00432-0283.gif4.7KBDownloadView
envhper00432-0269.tif176.3KBDownloadView
envhper00432-0259.gif6.6KBDownloadView
license.txt538bytesDownloadView
envhper00432-0294.tif234.3KBDownloadView
envhper00432-0275.gif6.8KBDownloadView
envhper00432-0263.tif235.6KBDownloadView
envhper00432-0286.gif3.4KBDownloadView
envhper00432-0268.tif200.8KBDownloadView
envhper00432-0283.tif115.1KBDownloadView
envhper00432-0276.gif6.2KBDownloadView
envhper00432-0251.gif7.5KBDownloadView
envhper00432-0249.gif7.5KBDownloadView
envhper00432-0278.tif201.6KBDownloadView
envhper00432-0250.gif6.2KBDownloadView
envhper00432-0290.gif7.1KBDownloadView
envhper00432-0248.tif214.5KBDownloadView
envhper00432-0266.gif5.3KBDownloadView
envhper00432-0267.gif5.1KBDownloadView
envhper00432-0289.gif6KBDownloadView
envhper00432-0293.gif7KBDownloadView
envhper00432-0277.tif203.4KBDownloadView
envhper00432-0264.tif168.3KBDownloadView
envhper00432-0285.gif7.6KBDownloadView
envhper00432-0284.gif5.7KBDownloadView
envhper00432-0277.gif6.9KBDownloadView
envhper00432-0282.gif6.3KBDownloadView
envhper00432-0265.tif170.2KBDownloadView
envhper00432-0260.tif152.8KBDownloadView
envhper00432-0252.gif6.6KBDownloadView
envhper00432-0279.gif2.8KBDownloadView
envhper00432-0261.gif7.6KBDownloadView
envhper00432-0288.tif159KBDownloadView
envhper00432-0269.gif6KBDownloadView
envhper00432-0287.gif5.9KBDownloadView
envhper00432-0291.tif258KBDownloadView
envhper00432-0286.tif77.6KBDownloadView
envhper00432-0293.tif243.2KBDownloadView
envhper00432-0274.tif220.1KBDownloadView
envhper00432-0273.gif7.3KBDownloadView
envhper00432-0255.gif5.5KBDownloadView
envhper00432-0261.tif249KBDownloadView
envhper00432-0284.tif153.8KBDownloadView
envhper00432-0258.tif246.3KBDownloadView
envhper00432-0266.tif161.5KBDownloadView
envhper00432-0291.gif7KBDownloadView
envhper00432-0247.nxml8.3KBDownloadView
envhper00432-0264.gif5.9KBDownloadView
envhper00432-0272.tif204.6KBDownloadView
envhper00432-0272.gif7KBDownloadView
envhper00432-0250.tif180.6KBDownloadView
envhper00432-0252.tif194KBDownloadView
envhper00432-0270.gif4.4KBDownloadView
envhper00432-0262.gif8KBDownloadView
envhper00432-0259.tif201.5KBDownloadView
envhper00432-0254.gif5.9KBDownloadView
envhper00432-0262.tif259.5KBDownloadView
envhper00432-0294.gif6.6KBDownloadView
envhper00432-0292.tif255KBDownloadView
envhper00432-0251.tif250.5KBDownloadView
envhper00432-0248.gif7KBDownloadView
envhper00432-0276.tif174.9KBDownloadView
envhper00432-0254.tif168.9KBDownloadView
envhper00432-0280.tif178.5KBDownloadView
envhper00432-0257.gif6.7KBDownloadView
envhper00432-0260.gif5.5KBDownloadView
envhper00432-0247.gif5.9KBDownloadView
envhper00432-0274.gif6.8KBDownloadView
envhper00432-0271.tif174.7KBDownloadView
envhper00432-0255.tif164.5KBDownloadView
envhper00432-0281.gif5.5KBDownloadView
envhper00432-0247.pdf9.4MBDownloadView
envhper00432-0256.gif6.8KBDownloadView
envhper00432-0247.txt247.8KBDownloadView
envhper00432-0278.gif6.9KBDownloadView
envhper00432-0282.tif186.5KBDownloadView
envhper00432-0271.gif6.1KBDownloadView
envhper00432-0253.tif180.7KBDownloadView
envhper00432-0253.gif6.5KBDownloadView
envhper00432-0279.tif65.8KBDownloadView
envhper00432-0275.tif203.3KBDownloadView
envhper00432-0249.tif251.5KBDownloadView
envhper00432-0292.gif7.2KBDownloadView
envhper00432-0268.gif6.7KBDownloadView
envhper00432-0270.tif91.2KBDownloadView
envhper00432-0287.tif156.4KBDownloadView
envhper00432-0285.tif243.7KBDownloadView
envhper00432-0289.tif165.1KBDownloadView
envhper00432-0290.tif243.6KBDownloadView
envhper00432-0258.gif7.7KBDownloadView