Topography and Land Cover of Watersheds Predicts the Distribution of the Environmental Pathogen Mycobacterium ulcerans in Aquatic Insects

Collection with item attached
2014_11
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/2151.do
DOI
http://dx.doi.org/10.1371/journal.pntd.0003298
journal_title
PLoS Neglected Tropical Diseases
eissn
1935-2735
publisher_name
Public Library of Science
article_id
10.1371/journal.pntd.0003298
article_title
Topography and Land Cover of Watersheds Predicts the Distribution of the Environmental Pathogen Mycobacterium ulcerans in Aquatic Insects
surname
Carolan
given_names
Kevin
email
kevin.carolan@ird.fr
address
Unité mixte de recherche (UMR) Maladies Infectieuses et Vecteurs: Écologie, Génétique, Evolution, et Contrôle (MIVEGEC) IRD-CNRS-Universities of Montpellier I and II, Centre IRD de Montpellier, Montpellier, France
UMR Territoires, Environnement, Télédétection et Information Spatiale (TETIS) CIRAD, Montpellier, France
Unité d'Epidémiologie de Maladies Emergentes, Institut Pasteur, Paris, France
surname
Garchitorena
given_names
Andres
address
Unité mixte de recherche (UMR) Maladies Infectieuses et Vecteurs: Écologie, Génétique, Evolution, et Contrôle (MIVEGEC) IRD-CNRS-Universities of Montpellier I and II, Centre IRD de Montpellier, Montpellier, France
Ecole des Hautes Etudes en Santé Publique, Rennes, France
surname
García-Peña
given_names
Gabriel E.
address
Unité mixte de recherche (UMR) Maladies Infectieuses et Vecteurs: Écologie, Génétique, Evolution, et Contrôle (MIVEGEC) IRD-CNRS-Universities of Montpellier I and II, Centre IRD de Montpellier, Montpellier, France
Centre de Synthèse et d'Analyse sur la Biodiversité -CESAB. Bâtiment Henri Poincaré, Domaine du Petit Arbois. Aix-en-Provence, France
surname
Morris
given_names
Aaron
address
Unité mixte de recherche (UMR) Maladies Infectieuses et Vecteurs: Écologie, Génétique, Evolution, et Contrôle (MIVEGEC) IRD-CNRS-Universities of Montpellier I and II, Centre IRD de Montpellier, Montpellier, France
Bournemouth University, School of Applied Sciences, Dorset, United Kingdom
surname
Landier
given_names
Jordi
address
Unité d'Epidémiologie de Maladies Emergentes, Institut Pasteur, Paris, France
Service d'épidémiologie et de santé publique, Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur, Yaoundé, Cameroun
surname
Fontanet
given_names
Arnaud
address
Unité d'Epidémiologie de Maladies Emergentes, Institut Pasteur, Paris, France
Chaire Santé et Développement, Conservatoire National des Arts et Métiers, Paris, France
surname
Le Gall
given_names
Philippe
address
Institut de Recherche pour le Développement (IRD), UR 072, Laboratoire Evolution, Génomes et Spéciation, UPR 9034, Centre National de la Recherche Scientifique (CNRS), Gif sur Yvette, France et Université Paris-Sud 11, Orsay, France
surname
Texier
given_names
Gaëtan
address
Service d'épidémiologie et de santé publique, Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur, Yaoundé, Cameroun
UMR 912 - SESSTIM - INSERM/IRD/Aix-Marseille Université Faculté de Médecine - 27, Marseille, France
surname
Marsollier
given_names
Laurent
address
ATOMycA, Inserm Avenir Team, CRCNA, Inserm U892, 6299 CNRS and LUNAM, Angers, France
surname
Gozlan
given_names
Rodolphe E.
address
Unité mixte de recherche (UMR) Maladies Infectieuses et Vecteurs: Écologie, Génétique, Evolution, et Contrôle (MIVEGEC) IRD-CNRS-Universities of Montpellier I and II, Centre IRD de Montpellier, Montpellier, France
Bournemouth University, School of Applied Sciences, Dorset, United Kingdom
UMR 207 BOREA IRD-MNHN-Université Pierre et Marie Curie, Muséum National d'Histoire Naturelle, Paris, France
surname
Eyangoh
given_names
Sara
address
Service de Mycobactériologie, Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur, Yaoundé, Cameroun
surname
Lo Seen
given_names
Danny
address
UMR Territoires, Environnement, Télédétection et Information Spatiale (TETIS) CIRAD, Montpellier, France
surname
Guégan
given_names
Jean-Francois
address
Unité mixte de recherche (UMR) Maladies Infectieuses et Vecteurs: Écologie, Génétique, Evolution, et Contrôle (MIVEGEC) IRD-CNRS-Universities of Montpellier I and II, Centre IRD de Montpellier, Montpellier, France
Ecole des Hautes Etudes en Santé Publique, Rennes, France
pub_date:2014-11-06
history_received:2014-08-01
history_accepted:2014-09-25
volume
8
issue
11
title
Background
p
An understanding of the factors driving the distribution of pathogens is useful in preventing disease. Often we achieve this understanding at a local microhabitat scale; however the larger scale processes are often neglected. This can result in misleading inferences about the distribution of the pathogen, inhibiting our ability to manage the disease. One such disease is Buruli ulcer, an emerging neglected tropical disease afflicting many thousands in Africa, caused by the environmental pathogen Mycobacterium ulcerans. Herein, we aim to describe the larger scale landscape process describing the distribution of M. ulcerans.
title
Methodology
p
Following extensive sampling of the community of aquatic macroinvertebrates in Cameroon, we select the 5 dominant insect Orders, and conduct an ecological niche model to describe how the distribution of M. ulcerans positive insects changes according to land cover and topography. We then explore the generalizability of the results by testing them against an independent dataset collected in a second endemic region, French Guiana.
title
Principal Findings
p
We find that the distribution of the bacterium in Cameroon is accurately described by the land cover and topography of the watershed, that there are notable seasonal differences in distribution, and that the Cameroon model does not predict the distribution of M. ulcerans in French Guiana.
title
Conclusions/Significance
p
Future studies of M. ulcerans would benefit from consideration of local structure of the local stream network in future sampling, and further work is needed on the reasons for notable differences in the distribution of this species from one region to another. This work represents a first step in the identification of large-scale environmental drivers of this species, for the purposes of disease risk mapping.
title
Author Summary
p
Many pathogens persist in the environment, and an understanding of where they are can assist in disease control, allowing us to identify areas of risk to local human populations. Herein, we use general linear models to describe the distribution of a particular environmental pathogen, Mycobacterium ulcerans, describing the landscape conditions correlated with the presence of this pathogen in local biota, and mapping the distribution of these habitats in a region of Cameroon, Africa. Our findings identify the importance of the watershed as a factor determining the distribution of the bacterium, where landscape conditions upstream of the sample site can influence the abundance of the bacterium in downstream sites. We find that the bacterium has notable seasonal changes in its distribution, between the wet and dry seasons, which may have implications for human health. We also discuss sensitivity of these models to extrapolation, finding that they work well in the African region and underperforming when extrapolated to another region in South America.
copyright
© 2014 Carolan et al This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Files in This Item
journal.pntd.0003298.xml130.7KBDownloadView