CONDOR: a database resource of developmentally associated conserved non-coding elements

Collection with item attached
2007_08
Basic Collection
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/162373.do
Title
CONDOR: a database resource of developmentally associated conserved non-coding elements
Description
Abstract Background Comparative genomics is currently one of the most popular approaches to study the regulatory architecture of vertebrate genomes. Fish-mammal genomic comparisons have proved powerful in identifying conserved non-coding elements likely to be distal cis- regulatory modules such as enhancers, silencers or insulators that control the expression of genes involved in the regulation of early development. The scientific community is showing increasing interest in characterizing the function, evolution and language of these sequences. Despite this, there remains little in the way of user-friendly access to a large dataset of such elements in conjunction with the analysis and the visualization tools needed to study them. Description Here we present CONDOR (COnserved Non-coDing Orthologous Regions) available at: http://condor.fugu.biology.qmul.ac.uk . In an interactive and intuitive way the website displays data on > 6800 non-coding elements associated with over 120 early developmental genes and conserved across vertebrates. The database regularly incorporates results of ongoing in vivo zebrafish enhancer assays of the CNEs carried out in-house, which currently number ~100. Included and highlighted within this set are elements derived from duplication events both at the origin of vertebrates and more recently in the teleost lineage, thus providing valuable data for studying the divergence of regulatory roles between paralogs. CONDOR therefore provides a number of tools and facilities to allow scientists to progress in their own studies on the function and evolution of developmental cis -regulation. Conclusion By providing access to data with an approachable graphics interface, the CONDOR database presents a rich resource for further studies into the regulation and evolution of genes involved in early development.
provenance
Made available in Cube on 2015-09-21T06:04:24Z (GMT). No. of bitstreams: 0
language
en
creator
Woolfe, Adam
Goode, Debbie K
Cooke, Julie
Callaway, Heather
Smith, Sarah
Snell, Phil
McEwen, Gayle K
Elgar, Greg
date
2007-08-30
accessioned
2015-09-21T06:04:24Z
available
2015-09-21T06:04:24Z
issued
2015-09-21
identifier
http://www.biomedcentral.com/1471-213X/7/100
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/162373.do
publisher
BioMed Central Ltd.
rights
Copyright 2007 Woolfe et al; licensee BioMed Central Ltd.
type
Database


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